LOGOChapter7RegulationofGeneExpressionineukaryotes7.1HistonesandTranscriptionalRegulation7.2Post-TranscriptionalRegulation7.3NuclearExport7.4RNAstability7.5Translationalcontrol7.6mRNAlocalization7.7Proteinregulation7.8ExperimentsKeypointsKeypointsGoSameDNA,differentcells相同的DNA、不同的细胞Neuralcells神经细胞Bloodcells血液细胞Amusclecell肌肉细胞Humancells人体细胞Opportunitiesforthecontrolofgen...
LOGOChapter7RegulationofGeneExpressionineukaryotes7.1HistonesandTranscriptionalRegulation7.2Post-TranscriptionalRegulation7.3NuclearExport7.4RNAstability7.5Translationalcontrol7.6mRNAlocalization7.7Proteinregulation7.8ExperimentsKeypointsKeypointsGoSameDNA,differentcells相同的DNA、不同的细胞Neuralcells神经细胞Bloodcells血液细胞Amusclecell肌肉细胞Humancells人体细胞Opportunitiesforthecontrolofgen...
Chapter6Translation-AAA---ASplicingExon1Exon2Exon3DNATranscriptionPre-mRNAMaturemRNAPolyadenylationIntron1Intron2Nuclearexport-AAA---ATranslationNucleusCytoplasmDegradationCapMaturemRNAProteinKeypointsKeypoints6.1TheGeneticCode6.2MechanismofTranslationinProkaryotes6.3TranslationinEukaryotes6.4tRNAStructureandWobble6.5ExperimentsKeypointsKeypoints6.1TheGeneticCode6.2tRNAStructureandWobble6.3Mech...
LOGOChapter5mRNAModificationsinEukaryotes5.1Capping加帽5.2Polyadenylation聚腺苷酸化5.3Splicing剪接5.4mRNAEditing编辑5.5ExperimentsContentsContentsGoCapping5.1真核生物转录产物:直接使用吗?Directionoftranscription5’3’3’-OH3’5’DNARNApolymeraseRibosome5’mRNAPeptidechain-AAA---ASplicingExon1Exon2Exon3DNATranscriptionPre-mRNAMaturemRNAPolyadenylationIntron1Intron2Nuclearexport-AAA---ATranslati...
LOGOChapter5mRNAModificationsinEukaryotes5.1Capping加帽5.2Polyadenylation聚腺苷酸化5.3Splicing剪接5.4mRNAEditing编辑5.5ExperimentsContentsContentsGoCapping5.1真核生物转录产物:直接使用吗?Directionoftranscription5’3’3’-OH3’5’DNARNApolymeraseRibosome5’mRNAPeptidechain-AAA---ASplicingExon1Exon2Exon3DNATranscriptionPre-mRNAMaturemRNAPolyadenylationIntron1Intron2Nuclearexport-AAA---ATranslati...
Chapter3TranscriptioninProkaryotes:MechanismandRegulation原核生物转录:机理与调控PromotersRNAPolymeraseTranscriptionmechanisminthreephasesMechanismoftranscriptionRegulationofgeneexpressioninprokayotesTheLacoperonWhyuseandRNAintermediate?TheTrpoperonMainPoints§1WhyuseanRNAintermediate?(为什么使用RNA作为中间物)Chromosomesarelargeandcomplex染色体庞大又复杂Chromosomesarelargeandc...
Chapter3TranscriptioninProkaryotes:MechanismandRegulation原核生物转录:机理与调控PromotersRNAPolymeraseTranscriptionmechanisminthreephasesMechanismoftranscriptionRegulationofgeneexpressioninprokayotesTheLacoperonWhyuseandRNAintermediate?TheTrpoperonMainPoints§1WhyuseanRNAintermediate?(为什么使用RNA作为中间物)Chromosomesarelargeandcomplex染色体庞大又复杂Chromosomesarelargeandc...
Chapter2DNAreplicationDNA复制DNAReplication/DNA复制Geneticinformationisalsopassedfromgenerationtogeneration.Acrucialpropertyoflifeisthateventhemostcomplexorganismsareabletobecopied.遗传信息也从一个世代到另一个世代进行传递。生命至关重要的特性是:即使是最复杂的生命也能够被复制出来。Semi-conservativereplicationInitiationofrepliactionSemi-discontinuousreplicationElongationofreplicationanditsprotein...